Nitrazepam and the elderly.
نویسندگان
چکیده
منابع مشابه
Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program. 1978.
1 To assess the potential hazards of nitrazepam therapy of insomnia in the elderly, adverse reactions to nitrazepam were studied in 2111 hospitalized medical patients who received the drug. 2 Manifestations of unwanted central nervous system (CNS) depression (such as drowsiness or 'hangover') were reported in 49 nitrazepam recipients (2.3%), and signs of unwanted CNS stimulation (such as nightm...
متن کاملNitrazepam in premedication.
The sedative effects of nitrazepam in a dose of 5 mg and 10 mg have been compared with Mandrax, a combination of methaqualone 250 mg with diphenhydramine 25 mg. Studies were carried out in gynaecological patients undergoing minor surgical operations using the scoring system previously described. The degree of sedation obtained after administration of the two dose levels of nitrazepam was compar...
متن کاملHypnotic accumulation and hangover in elderly inpatients: a controlled double-blind study of temazepam and nitrazepam.
The hypnotic and residual sedative effects of the first and seventh of seven regular night-time doses of nitrazepam 5 mg, temazepam 20 mg, and placebo were studied in 58 elderly inpatients. Plasma temazepam and nitrazepam concentrations rose by about 50% and 113% respectively between the mornings of day 1 and day 7. Patients reported sleeping well more often after the first dose of either hypno...
متن کاملPolymorphic acetylation of nitrazepam.
Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).
متن کاملBullous lesions in nitrazepam overdosage.
sided abdominal pain followed by bloody diarrhoea which rapidly improved without specific treatment. The bariumenema examination showed changes at the typical site which progressed from narrowing with marginal thumb-printing, through sacculation, to complete normality (Boley et al., 1963; Marston et al., 1966; Lea Thomas, 1968; Williams et al., 1969). The only unusual feature was the patient's ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1973
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5852.553-b